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COGNITIVE HEALTH

SynapseT™

SynapseT™ is a dietary supplement designed to significantly improve cognitive function, focus, attention, and decrease the inattention, hyperactivity and impulsivity.

​Helps to correct nutritional deficiencies observed in individuals with ADD / ADHD:
​Magnesium, Zinc, Vitamin B6 and fatty acids (EPA and DHA).
Helps to support cognitive health and/or brain function.


GO TO SYNAPSET MICROSITE

First Allegation:
Clinical studies have shown that children with ADHD, certain fatty acids are deficient and the intake of certain Omega-3, such as EPA, exerted a positive influence on their behavior.

Evidence in support of the first allegation
One of the disorders, possibly the most prevalent today in children, is attention deficit hyperactivity disorder (ADD or ADHD). ADHD is primarily characterized by persistent inattention and/or hyperactivity-impulsivity that occurs more frequently and severely than is generally observed. The American Psychiatric Association estimates that 3% to 5% of school-age children are ADHD (DSM-IV), whereas other sources report a greater occurrence. It is believed that it is about 35% in the U.S.  ADHD is the most common psychiatric disorder in children, which is why there is an increasing interest on the potential effects of diet on hyperactivity in childhood. Researchers have reported that various aspects of diet and the fatty acid metabolism of a child may have adverse effects on the comportment. Interestingly, many of the physical and behavioral symptoms related to a deficiency in essential fatty acids (for example, a lack of Omega-3) are similar to the symptoms described in patients with typical ADHD. It was therefore suggested that perhaps a dietary deficiency in Omega-3 fatty acids, or an alteration in the metabolic process of these fatty acids, may contribute to the syndrome ADHD. In support of this theory, physiological levels of higher Omega-3 were associated with a decrease in problems with inattention, hyperactivity, emotional problems, conduct problems, and increased prosocial behavior.​

Several scientific studies have been conducted to assess and confirm the hypothesis that Omega-3 (i.e. EPA and DHA) can treat and prevent ADHD. For numerous boys, a frequency increased behavioral problems (hyperactivity, impulsivity disorders behavior, anxiety, tantrums and sleep disturbances) were observed in children with lower levels of Omega-3 fatty acids. Administration of fish oil with high EPA report has significantly reduced the inattention and hyperactivity in children while an intake of DHA only has seen no improvement in other children with ADHD. In another study, a high ratio of EPA supplementation led to a reduction in symptoms and symptomatic control supported in a subgroup of children with ADHD.

​There are many scientific studies that indicate that the ASP is responsible for improvements in problems with inattention, hyperactivity and behavioral disorders. Although few studies have been done with a supplement with high intake of DHA, DHA alone gave no benefit. It appears that Omega-3 fatty acid of marine origin are somehow related to emotional control in adolescents who suffer from attention deficit and hyperactivity. The evidence from the literature therefore suggested that children with ADHD have lower levels of these fatty acids than normal and confirms the role of fatty acids Omega-3 and, specifically, EPA. The results demonstrate for the first time the relationship between fatty acids Omega-3 and emotional problems that accompany the disease. To ensure the desired effect, we made sure that our product contains the optimum dosage of EPA (per packet).
Second Allegation:
Helps correct nutritional deficiencies observed in individuals with ADD / ADHD utilizing magnesium, zinc, vitamin B6 and Omega-3 fatty acids (DHA and EPA).

Evidence in support of the second allegation
The following studies demonstrate that among individuals with ADHD magnesium levels, zinc, vitamin B6 and Omega-3 fatty acids are lower than normal on the one hand and that supplementation of these same ingredients can improve ADHD symptoms.

Magnesium deficiencies
In a study of children with ADHD, it was observed that 95% of them showed signs of magnesium deficiency. The results of a placebo without clinical trial in children with ADHD show that taking magnesium daily for 6 months decreased hyperactivity manifestations in children treated the supplement compared to those receiving the conventional treatment. The symptoms of attention deficit diminished for children who received magnesium. Positive results were also obtained in hyperactive children with simultaneous supplementation of magnesium and vitamin B6.

Zinc deficiency
According to several studies, zinc deficiency is associated with more pronounced ADHD symptoms. Furthermore, the results of two placebo-controlled trials conducted with children with ADHD indicate that a zinc supplement could help children with this condition. According to studies, zinc deficiency mimics the symptoms of ADHD. Some authors concluded, "Zinc is an essential co-factor in a huge number of different processes in the brain and body." The authors have linked zinc deficiency syndrome, "hyperadrenal," as well as, the production of melatonin and serotonin, which both can plausibly contribute to behavioral disturbances observed in ADHD.

Deficiencies in vitamin B6
A vitamin B6 deficiency is the cause of low levels of neurotransmitters such as serotonin that is observed in hyperactive children. Magnesium and vitamin B6 are interrelated. Vitamin B6 promotes the absorption of magnesium in cells while magnesium is required for the alkaline phosphatase to the absorption of vitamin B6 tissues. Children with ADHD have lower levels of magnesium in red blood cells. A study in children showed improvements in behavior; inattention, aggression, hyperactivity and after treatment with magnesium and vitamin B6.​

Combination of fatty acids Omega-3 zinc and magnesium
Our product is a combination of several elements 3 mentioned above. Some authors have shown variability in response to polyunsaturated fatty acids supplemented in children with ADHD. A more pronounced response was observed in those who have learning problems. It was then suggested that a combination of polyunsaturated fatty acids, zinc and magnesium may be more beneficial in these children, in which related to attention, behavior and emotional problems.

Summary of Features​:
Helps support cognitive health and/or brain function
Evidence in support of the third allegation
Evidence associated with this claim is found in the monograph “Fish Oil”
Reference monograph:  For products providing 100-5000 mg (EPA + DHA), at least 100 mg of DHA. Our product, per packet, has: 360 mg Omega-3 fatty acids DHA and 134 mg, therefore, met the conditions associated with the claim. 
Note: The dosage provides the consumption of 1-3 packets per day according to the target population.
Clinical studies have shown that children with ADHD have certain fatty acids which are deficient and the intake of certain Omega-3 such as EPA may have a positive influence on their behavior*.

​*These statements have not been evaluated by the U.S. Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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